The Appetite Hormone CART May Have Antidiabetic Effects

by Bidita Debnath on  July 2, 2016 at 12:04 AM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

The appetite hormone CART not only controls the sensation of satiety, but it also helps increase insulin secretion and decrease glucagon production, shows a research.
 The Appetite Hormone CART May Have Antidiabetic Effects
The Appetite Hormone CART May Have Antidiabetic Effects

CART (Cocaine and Amphetamine-Regulated Transcript) is a hormone that has mainly been studied in the brain's centre for appetite control.

The research group behind the new study made the previously unknown discovery that CART can also be found in human alpha and beta cells located in the pancreas, and that cells from people with type 2 diabetes contain more CART than cells in people who are healthy.

"The high glucose levels could be what triggers the production of CART", says Nils Wierup. The study also shows that CART increases the effect of GLP-1, an intestinal hormone that lowers blood sugar levels. GLP-1 represents the basis of the latest drugs against type 2 diabetes by stimulating the body's own insulin production.

Nils Wierup says that the new discoveries can eventually lead to new drugs against type 2 diabetes. However, because CART is currently only available for research purposes, the active molecule of the hormone needs to be further developed to create the equivalent effect artificially. Furthermore, the receptor that binds to the molecule is still unknown.

"However, we believe that we're getting close", says Nils Wierup and continues: "Once we find the unknown receptor, we hope to explain the biological mechanisms behind CART's function, which will hopefully lead to new and better drugs."

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Diet Pills Decreased Appetite Symptom Evaluation Increased Appetite Symptom Evaluation Hungry? - But you Just Ate! 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...