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Tau Protein Phosphorylation in Rats Subjected to Cerebral Ischemia-reperfusion Injury

by Himabindu Venkatakrishnan on  March 11, 2014 at 11:15 AM Research News   - G J E 4
Hyperphosphorylation of the microtu-bule-associated protein tau induced by transient brain ischemia, shows a study.
 Tau Protein Phosphorylation in Rats Subjected to Cerebral Ischemia-reperfusion Injury
Tau Protein Phosphorylation in Rats Subjected to Cerebral Ischemia-reperfusion Injury
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To further determine the mechanisms underlying these processes, Dr, Bo Song and co-workers from School of Life Sciences, Tsinghua University in China found for the first time that the interaction of tau with glycogen synthase kinase (GSK)-3β and protein phosphatase 2A is altered during transient brain ischemia. In addition, the researchers found that the neuroprotective function of lithium chloride may depend partly on the altered phosphorylation of tau, by regulating the associations between tau, GSK-3β and protein phosphatase 2A during cerebral ischemia.

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These findings were published in the Neural Regeneration Research (Vol. 8, No. 34, 2013).

Source: Eurekalert
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