Medindia

X

Success of Oligonucleotide Therapeutics Enabled by Modified DNA Backbone

by Himabindu Venkatakrishnan on  November 14, 2014 at 9:13 AM Research News   - G J E 4
The two oligonucleotide-based drugs on the market, that have recently been approved by U.S. FDA, have modified chemical backbone made of phosphorothioates. The therapeutic advantages of the phosphorothioate group and the new types of gene expression-regulation oligonucleotide drugs that it is enabling are detailed in a Review article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers. The article is available free on the Nucleic Acid Therapeutics website until December 13, 2014.
 Success of Oligonucleotide Therapeutics Enabled by Modified DNA Backbone
Success of Oligonucleotide Therapeutics Enabled by Modified DNA Backbone
Advertisement

In the article "Phosphorothioates, Essential Components of Therapeutic Oligonucleotides," Fritz Eckstein, Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany, describes how the chemical and biochemical properties of this significant nucleic acid modification have made DNA suitable for use as therapeutic agents. Initial applications focused on cleaving the mRNA product of genes to block protein production. Dr. Eckstein explores novel applications including microRNA and long non-coding RNA targets and the use of decoy oligonucleotides.

Advertisement
"We will advance the field of nucleic acid therapeutics by looking to key opinion leaders to educate and initiate the experienced and newcomers alike. In this review, Dr. Eckstein has produced a tour de force concerning the therapeutic application of phosphorothioates," says Executive Editor Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI.

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All