Medindia

X

Study Shows How Antidepressants Work in Brain

by Sheela Philomena on  November 9, 2013 at 10:52 AM Drug News   - G J E 4
A new study conducted by scientists has shed light on how antidepressants work in the human brain and may lead to the better antidepressants' development with few or no side effects.
 Study Shows How Antidepressants Work in Brain
Study Shows How Antidepressants Work in Brain
Advertisement

The article from Eric Gouaux, Ph.D., a senior scientist at OHSU's Vollum Institute and a Howard Hughes Medical Institute Investigator describes research that gives a better view of the structural biology of a protein that controls communication between nerve cells.

Advertisement
The article focuses on the structure of the dopamine transporter, which helps regulate dopamine levels in the brain.

Dopamine is an essential neurotransmitter for the human body's central nervous system; abnormal levels of dopamine are present in a range of neurological disorders, including Parkinson's disease, drug addiction, depression and schizophrenia.

Along with dopamine, the neurotransmitters noradrenaline and serotonin are transported by related transporters, which can be studied with greater accuracy based on the dopamine transporter structure.

The Gouaux lab's more detailed view of the dopamine transporter structure better reveals how antidepressants act on the transporters and thus do their work.

Another article published also dealt with a modified amino acid transporter that mimics the mammalian neurotransmitter transporter proteins targeted by antidepressants.

It gives new insights into the pharmacology of four different classes of widely used antidepressants that act on certain transporter proteins, including transporters for dopamine, serotonin and noradrenaline.

The second paper in part was validated by findings of the first paper - in how an antidepressant bound itself to a specific transporter.

The two papers have been published in journal Nature.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All