Medindia

X

Study Says Corticosteroids Not Effective for Treating Acute Sinusitis

by Sheela Philomena on  August 8, 2012 at 9:59 AM Drug News   - G J E 4
Corticosteroids show no benefit in treating acute sinusitis, states study published in CMAJ.
 Study Says Corticosteroids Not Effective for Treating Acute Sinusitis
Study Says Corticosteroids Not Effective for Treating Acute Sinusitis
Advertisement

The common cold is the main cause of acute sinusitis, which is characterized by inflammation of the nasal cavities, blocked nasal passages and sometimes headaches and facial pain. Allergies and bacteria can also cause the condition, which is uncomfortable and difficult to treat. Antibiotics are a common treatment, despite the fact that the cause is often viral and will not respond to antibiotics. Corticosteroids are increasingly being used to alleviate symptoms, although the evidence for efficacy is inconclusive.To determine the effectiveness of oral corticosteroids on acute rhinosinusitis (sinusitis), researchers from the Netherlands conducted a randomized, double-blind controlled trial involving 174 adults with clinically diagnosed acute rhinosinusitis.

Advertisement
Eighty-eight patients were randomized to a group that received 30 mg/d of prednisolone for a week and the remaining 86 received placebo. In the prednisolone group, 55 of 88 patients (62.5%) reported that their facial pain or pressure had resolved by day 7, versus 48 of 86 (55.8%) in the placebo group. Although there was a slight reduction of facial pain in the prednisolone group, the results were neither statistically nor clinically significant. Moreover, other patient-relevant outcomes revealed similar results."We found no clinically relevant effect of systemic corticosteroid monotherapy among patients with clinically diagnosed, uncomplicated acute rhinosinusitis," writes Dr. Roderick Venekamp, University Medical Centre Utrecht, Utrecht, the Netherlands, with coauthors."There is no rationale for the use of corticosteroids in the broad population of patients with clinically diagnosed acute rhinosinusitis," write the authors. "Future studies should focus on identifying subgroups of patients who may benefit from intranasal or systemic corticosteroid treatment."

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All