The reason why certain anticancer drugs cause heart failure in some patients has been discovered by scientists at the University of Texas MD Anderson Cancer Center, Houston.
Several types of cancer are characterized by overexpression of PDGFR proteins, and molecules that inhibit PDGFR signaling have proven useful anticancer therapeutics.
Colo-rectal Cancer - Management
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. Some people require a combination of treatments.
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. Some people require a combination of treatments.
Aarif Khakoo and colleagues have now identified a role for PDGFR-beta in mouse heart muscle cells that might help explain why inhibitors of PDGFR signaling can cause heart failure.
In the study, expression and activation of PDGFR-beta was found to increase dramatically in the hearts of mice exposed to pressure overload (a model of high blood pressure).
Prostate Cancer | Cancer of Prostate - Incidence, Prevention, Causes, Symptoms & Treatment
This cancer affects men over the age of 50 years and screening with rectal examination and PSA can help both in early detection and effective treatment
This cancer affects men over the age of 50 years and screening with rectal examination and PSA can help both in early detection and effective treatment
Further analysis indicated that PDGFR-beta in heart muscle cells contributes to the protective response to pressure overload by triggering the growth of new blood vessels, providing new insight into the physiologic functions of PDGFR-beta.
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About Cancer in Women
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades.
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades.
RAS
Oral Cancer | Mouth Cancer - Types, Causes, Symptoms, Diagnosis, Treatment & Prevention
Oral cancer is a cancer that develops in any part of the mouth. It is more common in men over 40.
Oral cancer is a cancer that develops in any part of the mouth. It is more common in men over 40.
