In mice Ginkgo biloba enhances neurogenesis and improves recovery following a stroke, finds new study.
Researchers at the University of Toledo, Ohio, found that Ginkgo biloba treated mice had enhanced neurogenesis, partly due to the increased protein expression of hemeoxygenase 1, an antioxidant gene that also has a role in neurogenesis. Pertinently, mice lacking the hemeoxygenase 1 gene were observed to have reduced neurogenesis after stroke.
AdvertisementThe study led by Dr. Zahoor A. Shah, Dr. Shadia E. Nada and Jatin Tulsulkar (graduate student) established that besides prevention, improving recovery following a stroke should become the prime focus of current stroke research. It was now found that neurogenesis was not only an ongoing process in adults, but could also be induced by pathological conditions like traumatic brain injury and ischemic stroke, and strategies that promoted endogenous neurogenesis as part of repair and regeneration process should be prioritized.
Neurogenesis in the adult brain involved not only the proliferation and migration of precursor cells known as stem cells/neural progenitor cells (NSCs) but also their functional integration into the neural network. Ischemia, though a potent inducer of proliferation and migration of NSCs, did not provided an environment conducive to their survival, differentiation and integration, and creating an environment with exogenous drugs was paramount to improving the number of NSCs that could result in improved brain repair and regeneration.
Zahoor A. Shah said that controversies and other ethical issues related to stem cell therapies make drug-induced enhanced neurogenesis a promising treatment strategy, besides one documented clinical trial recommending the use of Ginkgo biloba after ischemic stroke, further high quality and large-scale randomized controlled trials would be warranted to test its efficacy in stroke recovery.