X

Study Finds Evidence for a Therapeutic Effect of Braintone on Ischemic Brain Damage

by Rukmani Krishna on  August 17, 2013 at 11:50 PM General Health News   - G J E 4
A -A +
In the field of stroke, the importance of the neurovascular unit, which is comprised of neurons, endothelial cells and astrocytes, has received great attention, because stroke affects not only neurons, but also astrocytes and microvessels.
 Study Finds Evidence for a Therapeutic Effect of Braintone on Ischemic Brain Damage
Study Finds Evidence for a Therapeutic Effect of Braintone on Ischemic Brain Damage

Within the neurovascular unit, endothelial cells are critical for maintaining normal hemodynamic and metabolic homeostasis. Vascular damage during ischemia often leads to the disruption of the blood-brain barrier and dysregulation of vascular tonus, eventually causing substantial cell death. The Chinese herbs Rhodiolase, Notoginseng, Folium Ginkgo and Rhizoma Chuanxiong have been used for stroke ancillary treatment in China for years.

Braintone contains four major active ingredients: Radix Rhodiolase Essence (a major constituent of Rhodiola rosea L.), Radix Notoginseng Essence, Folium Ginkgo Essence and Rhizoma Chuanxiong. A recent study published in the Neural Regeneration Research (Vol. 8, No. 19, 2013) combined novel in vivo and in vitro experiments to show that Braintone dose-dependently increased the expression of hypoxia inducible factor 1α, heme oxygenase-1 and vascular endothelial growth factor in the ischemic cortex of rats with middle cerebral artery occlusion.

Braintone-containing serum increased levels of hypoxia-inducible factor 1α mRNA and protein, and elevated vascular endothelial growth factor mRNA and heme oxygenase-1 protein expression in a dose-dependent manner in human umbilical vein endothelial cells after glucose-oxygen deprivation. Collectively, these experimental findings suggest that Braintone has neuroprotective effects on ischemia-induced brain damage via the up-regulation of hypoxia-inducible factor 1α, heme oxygenase-1 and vascular endothelial growth factor expression in vascular endothelial cells.

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

Ask an Expert

C
If you have a question about health related issues, you can now post it in our Ask An Expert section on our community website Medwonders.com and get answers from our panel of experts.

Most Popular News on Medindia

P
M
X

Ask an Expert

Ask an Expert+
s
Calcium Plus Vitamin D Supplementation Does Not R...
 Calcium Plus Vitamin D Supplementation Does Not Reduce Joint Symptoms in Postmenopausal Women: Study
S  Excess Fat Helped 39-year-old Survive Flesh-eating Bug
Excess Fat Helped 39-year-old Survive Flesh-eatin...