Study Finds Drug Cuts Fear Akin to Post-Traumatic Stress Disorder Experiences in Mice

Researchers in a new study found mice previously exposed to traumatic situations demonstrate a more persistent memory of fear conditioning-acquired by associating an acoustic stimulus with an aversive stimulus-and lack the ability to inhibit this fear.

This phenomenon is similar to that of people who suffer from Post-Traumatic Stress Disorder (PTSD), an anxiety disorder which appears after being exposed to highly traumatic situations, such as a violent attack, a natural disaster or physical abuse.

Post Traumatic Stress Disorder (PTSD) - Causes, Symptoms, Risk Factors, Complications, Dignosis, Treatment
Post Traumatic Stress Disorder (PTSD), is a mental condition triggered by a traumatic event. PTSD treatment includes pyschotherapy, behavior therapy and medications.

In the study, researchers verified that the 7,8-Dihydroxyflavone injected into mice previously subjected to a traumatic experience made them extinguish fear conditioning quicker.

The enhancement of this new learning is the result of 7,8-Dihydroxyflavone activating the TrkB receptors in the brain, probably those found in the amygdala, which are essential for emotional learning and memory.

Chronic administration of foods rich in flavonoids in lab animals has demonstrated neuroprotective effects in aged rodents, but the activation of TrkB receptors produced by these foods is surely low compared to the effects of 7,8-Dihydroxyflavone.

Phobias - Facts, Causes, Symptoms, Diagnosis, Treatment, Prevention
A phobia is an irrational and exaggerated fear of an object or a situation that in reality, poses little or no actual danger.

TrkB receptors in the brain are activated in mammals by the BDNF protein. There are different pathologies, such as depression or anxiety disorders, in which this protein shows alterations in its function.

Unfortunately, administration of the BDNF protein as a drug is limited given that a large part of the amount injected does not permeate the blood-brain barrier and cannot access the brain. Very recent studies have demonstrated that 7,8-Dihydroxyflavone is the first drug to imitate BDNF actions and enter the brain with much more efficacy than the protein, thus revealing therapeutic actions in animal models suffering from Alzheimer's, strokes, Parkinson's and/or depression.

NGO's Crusade Against the Crime of Child Sexual Abuse
Preventing child sexual abuse and restoring the physical and mental wellness of every abused child is the mark of any civilized society, says Tulir, an NGO in India.

The results obtained in this study postulate that 7,8-Dihydroxyflavone as a drug could be an useful treatment for disorders based on fear such as PTSD, panic attacks and phobias.

Source-ANI