Advertisement

Most Popular on Medindia

P
M

Study Examines Effect of Hypothermia in Treating Adults With Severe Meningitis

by Kathy Jones on  October 13, 2013 at 9:52 PM Research News   - G J E 4
A new study led by Bruno Mourvillier from Université Paris Diderot, Sorbonne Paris Cité, Paris, is looking into whether treating comatose patients suffering from bacterial meningitis with hypothermia could help improve functional outcome compared to standard care.
 Study Examines Effect of Hypothermia in Treating Adults With Severe Meningitis

Among adults with bacterial meningitis, the death rate and frequency of neurologic complications are high, indicating the need for new therapeutic approaches. Clinical trials of patients with trauma who were treated with hypothermia have shown a decrease of intracranial pressure, suggesting a potential benefit of this technique in bacterial meningitis, according to background information in the article.

The randomized trial conducted in 49 intensive care units in France between February 2009 and November 2011 assessed 130 patients for eligibility and randomized 98 comatose adults with community acquired bacterial meningitis to the hypothermia group, where patients received a loading dose of 39°F cold saline and were cooled to 90°F to 93°F for 48 hours, or standard care.

The trial was stopped early because of concerns over excess mortality in the hypothermia group (25 of 49 patients [51 percent]) compared with the control group (15 of 49 patients [31 percent]). At 3 months, 86 percent in the hypothermia group compared with 74 percent in the control group had an unfavorable outcome (as gauged via the Glasgow Outcome Scale [a functional assessment inventory]).

"In conclusion, our trial does not support the use of hypothermia in adults with severe meningitis. Moderate hypothermia did not improve outcome in patients with severe bacterial meningitis and may even be harmful. Our results may have important implications for future trials on hypothermia in patients presenting with septic shock or stroke. Careful evaluation of safety issues in these future and ongoing trials are needed," the authors write.



Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

Ask an Expert

C
If you have a question about health related issues, you can now post it in our Ask An Expert section on our community website Medwonders.com and get answers from our panel of experts.
X

Ask an Expert

Ask an Expert+
s
Study Finds Same-Hospital Readmission Rates are a...
 Study Finds Same-Hospital Readmission Rates are an Unreliable Predictor for All-Hospital Readmission Rate
S  New Therapy Gives Hope to Multiple Sclerosis Sufferers
New Therapy Gives Hope to Multiple Sclerosis Suff...