Medindia

X

Stem Cell Transplantation can Stimulate Generation of Neurons Following Alzheimer's Disease

by Kathy Jones on  July 12, 2014 at 10:25 PM Genetics & Stem Cells News   - G J E 4
Researchers revealed that they were able to stimulate the process of neurogenesis in the brain of adult rat or mouse models with Alzheimer's disease (AD) through transplantation of mesenchymal stem cells.
 Stem Cell Transplantation can Stimulate Generation of Neurons Following Alzheimer's Disease
Stem Cell Transplantation can Stimulate Generation of Neurons Following Alzheimer's Disease
Advertisement

Few studies are reported on the therapeutic effect of adipose-derived stem cells (ADSCs) transplantation in mice with AD and on the effect on oxidative injury and neurogenesis in the brain of AD mice. Dr. Yufang Yan and her team, School of Life Sciences, Tsinghua University, China transplanted ADSCs into the hippocampus of APP/PS1 transgenic AD model mice. ADSCs transplantation reduced oxidative stress, promoted neurogenesis in both the subgranular and subventricular zone, and thereby improved the cognitive impairment in APP/PS1 transgenic AD mice. These results provide theoretical and experimental evidence for AD treatment with ADSCs. These findings were published in Neural Regeneration Research (Vol. 9, No. 8, 2014).

Advertisement


Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All