A new method of conception raises hopes for treating infertility problems in humans. Researchers have created rudimentary mouse sperm from stem cells with which on fertilization has resulted in healthy newborn mice.
The experiment was conducted by a team of Chinese researchers from the Nanjing Medical University and their findings were published in the Journal Cell Stem Cell
‘Immature sperm grown from embryonic mouse stem cells fertilizes with eggs to produce offspring. This technique may help infertile men in future.’
Scientists first isolated embryonic mouse stem cells and created primordial germ cells (PGC), a precursor to sperm and eggs. Then testicular tissue from newborn mice and other molecules were added to these primordial germ cells. After a period of 14 days, they developed into spermatids, non-motile sperms through meiosis. These spermatids were fertilized with eggs to produce nine baby mice.
Dr.Jiahao Sha, who co-led the research, said, "If proven to be safe and effective in humans, our platform could potentially generate fully functional sperm for artificial insemination or in-vitro fertilization techniques. Because currently available treatments do not work for many couples, we hope that our approach could substantially improve success rates for male infertility."