Although there is increasing evidence that sleep disorders are
common in individuals with chronic kidney disease (CKD), its link with CKD progression is
Not getting enough quality sleep was linked with worsening kidney
function in a study of patients with chronic kidney disease. The
findings will be presented at ASN Kidney Week 2016.
‘Each additional hour of nighttime sleep in individuals with chronic kidney disease was linked with a 19% lower risk of developing kidney failure.’
To investigate, Ana C. Ricardo (University of Illinois at
Chicago) and her colleagues examined the sleep patterns of 432 adults
with CKD. Participants wore a wrist monitor for five to seven days to measure
sleep duration and quality, and their health was followed for a median
of 5 years.
Participants slept an average of 6.5 hours/night, and during
follow-up, 70 individuals developed kidney failure and 48 individuals
died. After adjusting for sociodemographic factors, body mass index,
blood pressure, diabetes, cardiovascular disease, and baseline kidney
function, each additional hour of nighttime sleep was linked with a 19%
lower risk of developing kidney failure.
There was also a significant
association between sleep quality and kidney failure risk: each 1%
increase in sleep fragmentation was linked with a 4% increase in the
risk of developing kidney failure. Also, patients who experienced
daytime sleepiness were 10% more likely to die during follow-up than
those who were not sleepy during the day.
"Short sleep and fragmented sleep are significant, yet unappreciated
risk factors for CKD progression," said Dr. Ricardo. "Our research adds
to the accumulating knowledge regarding the importance of sleep on
kidney function, and underscores the need to design and test clinical
interventions to improve sleep habits in individuals with CKD."