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Seizure Risk of Anti-Shivering Agent Meperidine is Highly Overstated

by Dr. Trupti Shirole on  November 27, 2015 at 9:02 AM Drug News   - G J E 4
Meperidine is an opioid analgesic that is commonly used to control shivering in accidental or therapeutic hypothermia. This drug has previously been linked to increased seizure risk. However, a new study finds little published evidence to support this risk.
 Seizure Risk of Anti-Shivering Agent Meperidine is Highly Overstated
Seizure Risk of Anti-Shivering Agent Meperidine is Highly Overstated
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The authors concluded, "While use of meperidine for pain relief has declined, its role as an effective anti-shivering agent should continue to be explored." The study is published in Therapeutic Hypothermia and Temperature Management.

‘Meperidine has previously been linked to increased seizure risk. A review of medical literature suggested few cases of meperidine-associated seizures. In many of the cases, coexisting illnesses, conditions, or other factors were responsible for the increased risk of seizures.’
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The research team reviewed 45 years of medical literature and found relatively few cases of meperidine-associated seizures. In many of the cases, coexisting illnesses, conditions, or other factors could have contributed to or explained the increased risk of seizures.

Source: Eurekalert
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