Seizure Risk of Anti-Shivering Agent Meperidine is Highly Overstated

by Dr. Trupti Shirole on  November 27, 2015 at 9:02 AM Drug News
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Meperidine is an opioid analgesic that is commonly used to control shivering in accidental or therapeutic hypothermia. This drug has previously been linked to increased seizure risk. However, a new study finds little published evidence to support this risk.
 Seizure Risk of Anti-Shivering Agent Meperidine is Highly Overstated
Seizure Risk of Anti-Shivering Agent Meperidine is Highly Overstated

The authors concluded, "While use of meperidine for pain relief has declined, its role as an effective anti-shivering agent should continue to be explored." The study is published in Therapeutic Hypothermia and Temperature Management.

The research team reviewed 45 years of medical literature and found relatively few cases of meperidine-associated seizures. In many of the cases, coexisting illnesses, conditions, or other factors could have contributed to or explained the increased risk of seizures.

Source: Eurekalert

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