Medindia

X

Scientists Identify Potential Therapeutic Target for Tobacco-Related Lung Cancers

by Kathy Jones on  February 12, 2012 at 10:46 PM Cancer News   - G J E 4
The immune response regulator IKBKE (serine/threonine kinase) plays two roles in tobacco-related non-small cell lung cancers, say researchers.

Tobacco carcinogens induce IKBKE and, in turn, IKBKE induces chemotherapy resistance.
 Scientists Identify Potential Therapeutic Target for Tobacco-Related Lung Cancers
Scientists Identify Potential Therapeutic Target for Tobacco-Related Lung Cancers
Advertisement

"IKBKE is a newly identified oconogene, a gene linked to cancer," said study lead author Jin Q. Cheng, Ph.D., M.D., who studies genetic alterations and their molecular mechanisms in cancer.

Advertisement
"In our study, we demonstrated that IKBKE is a STAT 3 target gene and is induced by tobacco. STAT3 is a signaling and transcription gene that is activated in various types of cancer and is required for cell transformation," he explained.

As a "transcription factor" STAT3 plays a key role in many cellular processes, such as cell growth and programmed cell death, or "apoptosis."

"It has been well documented that STAT3 is activated by growth factors and environmental carcinogenesis, such as nicotine," said Cheng.

"STAT3 directly binds to the IKBKE promoter and induces IKBKE transcription," he added.

Tobacco smoke is the strongest documented tumor initiator and promoter in lung cancer. The underlying molecular mechanism is still largely unknown.

"IKBKE is induced by tobacco carcinogens and mediates tobacco action in promoting lung cancer cell survival. Armed with this knowledge, interventions targeting the IKBKE pathway could be developed," said Cheng.

Cheng and his colleagues found that when STAT3 induces IKBKE expression, IKBKE's expression induces chemotherapy resistance. Conversely, "knocking down" IKBKE sensitizes cells to chemotherapy, suggesting that there is a therapeutic role for targeting IKBKE.

The study was published in a recent issue of Oncogene.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All