Medindia

X

Rotten Egg Gas Plays Important Role in Autoimmune Disease: University of Pennsylvania

by Bidita Debnath on  August 12, 2015 at 11:59 PM Research News   - G J E 4
Hydrogen sulfide present in rotten eggs plays an important role in autoimmune disease. Our immune system contains a built-in brake in the form of regulatory T cells, or Tregs.
 Rotten Egg Gas Plays Important Role in Autoimmune Disease: University of Pennsylvania
Rotten Egg Gas Plays Important Role in Autoimmune Disease: University of Pennsylvania
Advertisement

These Tregs ensure that inflammatory responses don't get out of hand and do damage. In autoimmune diseases, sometimes these Treg cells don't act as they should. Songtao Shi of the University of Pennsylvania said that H2S was very interesting, adding that high levels of the gas were toxic, but our body maintains it at a certain level and our cells produce it.

Advertisement
In a series of experiments, Shi and his team observed that mice with reduced H2S production had large numbers of methyl groups on the Foxp3 gene, tags which repress the gene's expression. The team's work revealed that H2S regulates the expression of Tet1 and Tet2 by modifying a transcription factor called NFYB by adding a sulfur atom to it, a process called sulfhydration.

Reducing H2S levels led to reduced expression of Tet1 and Tet2 in T cells and, consequently, impaired function and development of Tregs. Again, the researchers showed they could partially reverse these effects by adding back a source of H2S. Shi concluded that it was clear that H2S has a very important role to play in immune regulation.

The study is published in the journal Immunity.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All