Review Examines Crohn's Disease Relapse After Surgery

Crohn’s disease is a type of inflammatory bowel disease that affects the lining of the digestive tract. Some patients with Crohn’s disease undergo surgery to remove part or the entire large intestine. But even surgery does not cure the condition, and many patients relapse after surgery.

A new review and analysis of published studies provides insights on the rates of relapse and predictors of relapse among Crohn's disease patients who underwent surgical removal of the entire large intestine (total colectomy) and the creation of a permanent ileostomy (an opening in the abdominal wall).

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‘Some patients who undergo surgery for Crohn’s disease are 3.2-times more likely to have a recurrence.’

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In the analysis of 18 studies, the risk of recurrence was 28.0%, with a 5- and 10-year median cumulative rates of 23.5% and 40%, respectively.

Patients with a history of Crohn's disease that affected the terminal ileum (the last part of the small intestine) were 3.2-times more likely to have recurrence than those without.

"Crohn's disease patients who are having total colectomy and ileostomy have a low risk of recurrence. These patients should be monitored, and treatment started in case of recurrence," said Dr Siddharth Singh, senior author of the Alimentary Pharmacology and Therapeutics article.

Combined Medical and Surgical Care Plan Improve Outcomes for Crohn's Disease
Prior to the introduction of an immunosuppressant medication called infliximab in 1998, septic perianal Crohn's disease was typically treated with surgery.

"This is especially important for those patients who ever had Crohn's disease involving the last part of the small intestine."

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A new study reveals that the development of a statistical model is key to understanding the genetic factors that affect the risk of Crohn's disease.

Source-Eurekalert

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