Medindia

X

Retinoid Deficiency in Utero Linked to Bronchial Hyperresponsiveness in Mice

by Kathy Jones on  January 12, 2014 at 5:54 PM Research News   - G J E 4
It is well-known that asthma and COPD patients are subject to debilitating bronchospasm as a result of airways that are hyperresponsive to stimuli.
 Retinoid Deficiency in Utero Linked to Bronchial Hyperresponsiveness in Mice
Retinoid Deficiency in Utero Linked to Bronchial Hyperresponsiveness in Mice
Advertisement

Factors that lead to the development of airway hyperresponsiveness are not well characterized. In this issue of the Journal of Clinical Investigation, Wellington Cardoso and colleagues at the Boston University School of Medicine reveal that mice born to mothers with retinoid deficiency during pregnancy are at increased risk of developing airway hyperesponsiveness. Prenatal retinoid deficiency promoted altered airway development and lung differentiation. Bronchial hyperresponsiveness and abnormal phenotypes persisted throughout the postnatal period regardless for vitamin A status in the adult. These results suggest that retinoid signaling in the lung is important for proper airway development and prevention of inappropriate pulmonary inflammatory responses.

Advertisement


Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All