Resveratrol may Protect Against Hearing Loss

Red wine and grapes may have the potential to protect against hearing loss and cognitive decline, find researchers.

The study from Henry Ford Hospital in Detroit showed that healthy rats are less likely to suffer the long-term effects of noise-induced hearing loss when given resveratrol before being exposed to loud noise for a long period of time.

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"Our latest study focuses on resveratrol and its effect on bioinflammation, the body's response to injury and something that is believed to be the cause of many health problems including Alzheimer's disease, cancer, aging and hearing loss," said study lead author Michael D. Seidman, director of the Division of Otologic/Neurotologic Surgery in the Department of Otolaryngology-Head and Neck Surgery at Henry Ford Hospital.

"Resveratrol is a very powerful chemical that seems to protect against the body's inflammatory process as it relates to aging, cognition and hearing loss."

Noise-induced hearing loss not only impacts a person's ability to hear, it can cause difficulties with sleep and communication, and even raises the risk for heart disease by increasing a person's blood pressure, lipids and blood sugar.

Presbycusis (Age-related Hearing Loss)-Causes-Symptoms-Diagnosis-Treatment-FAQs
Presbycusis (age related hearing loss) is the gradual loss of hearing that occurs as people get older. Presbycusis involves progressive sensorineural hearing loss.

Dr. Seidman and his colleagues have published multiple papers exploring noise-induced hearing loss, as well as the use of resveratrol, a grape constituent noted for its antioxidant and anti-inflammatory properties.

The latest study focuses the inflammatory process as it relates to aging, cognition and hearing loss.

Anatomy of Ear and Hearing
Ear converts sound waves into electrical impulses that are transmitted to the temporal lobe of the brain through the auditory nerve. It consists of outer, inner and middle sections.

It was designed to identify the potential protective mechanism of resveratrol following noise exposure by measuring its effect on cyclooxygenase-2 (or COX-2, key to the inflammatory process) protein expression and formation of reactive oxygen species, which plays an important role in cell signaling and homeostasis.

The study found that acoustic overstimulation causes a time-depended, up-regulation of COX-2 protein expression. And, resveratrol significantly reduces reactive oxygen species formation, inhibits COX-2 expression and reduces noise-induced hearing loss following noise exposure in rats.

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Many academic institutions will hire volunteers for a national, phase II clinical trial to inspect the effects of resveratrol on persons with mild to moderate dementia owing to Alzheimer's disease.

"We've shown that by giving animals resveratrol, we can reduce the amount of hearing and cognitive decline," notes Dr. Seidman.

Ultimately, these findings suggest that resveratrol may exert a protective effect from noise-induced hearing loss by the inhibition of COX-2 expression and reactive oxygen species formation, although other mechanism may also be involved.

The study is published online this week ahead of print in the journal Otolaryngology-Head and Neck Surgery.

Source-ANI