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Researchers Identify Tumor Suppressor Gene for Acute Myeloid Leukemia

by Dr. Trupti Shirole on  September 25, 2015 at 6:46 PM Cancer News   - G J E 4
Acute myeloid leukemia (AML) is a blood cancer striking mostly older individuals. Researchers have now identified a gene that can act as a tumor suppressor for AML.
 Researchers Identify Tumor Suppressor Gene for Acute Myeloid Leukemia
Researchers Identify Tumor Suppressor Gene for Acute Myeloid Leukemia
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The findings showed that expression of the protein-coding gene hnRNP K is significantly reduced in AML patients who carry a specific genetic deletion. Mice studies revealed that reduced activity of this gene was associated with blood cancer. This could be important for investigating how best to target treatment of AML.

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Sean Post, assistant professor at The University of Texas MD Anderson Cancer Center in the US, said, "Our data implicates hnRNP K in the development of blood disorders and suggests it acts as a tumor suppressor. Both in vivo and in vitro results indicate that hnRNP K achieves this through regulation of key genetic pathways. Our study found that hnRNP K expression must be maintained for proper cellular regulation and to prevent tumor formation."

The study was published in Cancer Cell.

Source: IANS
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