The role played by acetylcholine-activated inward-rectifying potassium current in cardiac pacemaker activity and heart rate regulation has been identified by researchers, according to a new study published in the Journal of General Physiology.
The heart rate increases in response to fear or exercise, when the body's sympathetic nervous system activates the "fight or flight" stress response. After sympathetic stimulation, the heart rate is brought back to normal by the parasympathetic nervous system, which regulates the body at rest. Parasympathetic regulation of the heart rate is initiated when acetylcholine released from the vagus nerve spurs a chain of events that activate IKACh
in the sinoatrial node—the pacemaker of the heart—to reduce the heart rate. However, the precise role of IKACh
is not fully understood.
To find out more, researchers used mice lacking a specific gene required for IKACh
to investigate the consequences of its loss. The mice showed a moderate increase in resting heart rate compared with that in a control group, and they displayed a significant delay in the recovery of resting heart rate after stress, exercise, or administration of a drug that simulated activation of the fight or flight response. The results indicate that IKACh
plays a critical role in both of these parasympathetic cardiac functions.