Researchers Identify Key to Cure Bloodstream Malaria Infections

How malaria manipulates the immune system to allow the parasite to persist in the bloodstream has been discovered by researchers.

By rescuing this immune system pathway, University of Iowa researchers and colleagues were able to cure mice of bloodstream malaria infections.

Malaria - Causes, Symptoms, Diagnosis, Prevention, Treatment
Malaria is caused by a parasite that enters blood through the bite of an infected mosquito. It is characterized by fever, vomiting, shivering, sweating and other symptoms.

The findings could point the way to a new approach for treating malaria that does not rely on vaccination and is not susceptible to the parasite's notorious ability to develop drug resistance.

"Malaria is chronic, prolonged infection and the host immune defense has a tough time clearing it and sometimes it never clears it," said Noah Butler, Ph.D., UI postdoctoral research scholar and lead study author.

"We've determined that this prolonged infection actually drives dysfunction of the immune cells that are supposed to be fighting the infection, which in essence allows further persistence of the parasite infection," Butler explained.

About Mosquito Diseases
Mosquito-borne diseases, like malaria, filaria, dengue, etc are common in places conducive of mosquito breeding. Swamps, ponds and stagnated drainage provide optimal breeding ground for mosquitoes.

More specifically, the study showed that the malaria parasite stimulate these key immune cells (known as CD4+ T cells) so that they continuously express molecules called inhibitory receptors.

Under normal circumstances, these molecules help to "apply the brakes" to the immune response and prevent over-activation that can be harmful.

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Saliva represents a potential alternative to blood for the assessment of anti-malarial antibody levels.

However, by keeping the mechanism turned on, the malaria parasite damps down the immune response significantly, reducing the T cells' ability to fight the parasite and allowing it to persist.

Importantly, the team also showed that blocking the action of the inhibitory receptor molecules resulted in immediate and complete clearance of the malaria parasite.

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"When we blocked the function of these molecules, we took the brakes off the host's immune response and everything got better - the overall immune response was dramatically improved and there was immediate control and accelerated clearance of the parasite," noted John Harty, Ph.D., professor of microbiology and pathology at the UI Carver College of Medicine and senior study author.

"These findings suggest an alternative approach for the treatment of existing malaria infection," he concluded.

Harty noted that the current study was done in mice and it is not yet known if the same approach will work in humans.

The findings were published Dec. 11 in the Advance Online Publication of the journal Nature Immunology.

Source-ANI