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Researchers Find Therapeutic Effects When Normobaric Oxygen Is Preconditioned for Cerebral Ischemic Injury

by Rukmani Krishna on  December 27, 2013 at 11:39 PM General Health News   - G J E 4
Rapid and non-invasive characteristics can be found in normobaric oxygen. It may also have therapeutic effects on ischemic/hypoxic disease.
 Researchers Find Therapeutic Effects When Normobaric Oxygen Is Preconditioned for Cerebral Ischemic Injury
Researchers Find Therapeutic Effects When Normobaric Oxygen Is Preconditioned for Cerebral Ischemic Injury
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Dr. Chunhua Chen and colleagues from Peking University, China found that in rats which inhaled normobaric oxygen before focal cerebral ischemia, neurological deficits were improved and infarct volume was reduced; the expression of hypoxia-inducible factor-1α, Notch-1, vascular endothelial growth factor and erythropoietin were increased; neurological deficit scores increased; the hypoxia-inducible factor inhibitor 2-methoxyestradiol treatment could suppress the protective effect of normobaric oxygen. Given these observations, normobaric oxygen exposure could prevent cerebral ischemic/reperfusion injury, and this protective effect might be exerted via regulating the hypoxia-inducible factor signaling pathway. This finding, published in the Neural Regeneration Research (Vol. 8, No. 31, 2013), illustrates the beneficial effects of normobaric oxygen application as a potential treatment strategy.

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Source: Eurekalert
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