Medindia

X

Researchers Find a Promising Way to Turn Pain Off

by Kathy Jones on  November 28, 2014 at 5:04 PM Research News   - G J E 4
Researchers may have found the perfect pain relief tactic after identifying a receptor that plays a crucial role in blocking the pain pathway in the human body.
 Researchers Find a Promising Way to Turn Pain Off
Researchers Find a Promising Way to Turn Pain Off
Advertisement

Dr. Daniela Salvemini at Saint Louis University and colleagues have discovered a way to block a pain pathway in animal models of chronic neuropathic pain including pain caused by chemotherapeutic agents and bone cancer pain suggesting a promising new approach to pain relief.

Advertisement
They demonstrated that turning on a receptor in the brain and spinal cord counteracts chronic nerve pain in male and female rodents. Activating the A3 receptor - either by its native chemical stimulator, the small molecule adenosine, or by powerful synthetic small molecule drugs invented at the NIH - prevents or reverses pain that develops slowly from nerve damage without causing analgesic tolerance or intrinsic reward (unlike opioids).

Salvemini said that their findings suggest that the goal could be achieved by focusing the future work on the A3AR pathway in particular, as its activation provided robust pain reduction across several types of pain.

Researchers were excited to note that A3AR agonists are already in advanced clinical trials as anti-inflammatory and anticancer agents and show good safety profiles.

The research is published in the medical journal Brain.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All