Researchers Discover How Rho-associated Protein Kinase Modulates Neurite Extension

by Rukmani Krishna on  December 27, 2013 at 11:33 PM General Health News
RSS Email Print This Page Comment bookmark
Font : A-A+

An essential regulator of cytoskeletal dynamics during the process of neurite extension is rho-associated protein kinase. However, whether Rho kinase regulates microtubule remodeling or the distribution of adhesive proteins to mediate neurite outgrowth remains unclear.
 Researchers Discover How Rho-associated Protein Kinase Modulates Neurite Extension
Researchers Discover How Rho-associated Protein Kinase Modulates Neurite Extension

By using the ROCK inhibitor, Y-27632, and the agonist, lysophosphatidic acid, Kenen Chen and colleagues from First Affiliated Hospital of Jinan University in China observed that neurite outgrowth, microtubule remodeling and vinculin redistribution were tightly regulated by ROCK. They found that lysophosphatidic acid inhibited neurite outgrowth, which could be reversed by Y-27632.

Meanwhile, reorganization of microtubules was noticed during these processes, as indicated by their significant changes in the soma and growth cone. These findings, published in the Neural Regeneration Research (Vol. 8, No. 32, 2013), suggest that Rho kinase regulates rat hippocampal neurite growth and microtubule formation via a mechanism associated with the redistribution of vinculin.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Magical Millets for Your Health The Basics of Baby Food Diet and Nutrition Tips for Athletes Nutrition IQ 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive