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Researchers Develop Practical Technique to Produce Promising Anticancer Substance on Large Scale

by Kathy Jones on  January 18, 2013 at 8:34 PM Cancer News   - G J E 4
A new article published in the Journal of Medicinal Chemistry reports on the development of a technique through which scientists can produce large amounts of a promising new anticancer substance which kills off cancer cells in a different way compared to existing medicines.
 Researchers Develop Practical Technique to Produce Promising Anticancer Substance on Large Scale
Researchers Develop Practical Technique to Produce Promising Anticancer Substance on Large Scale
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Isamu Shiina and colleagues explain that the substance, AMF-26, showed promise against certain forms of cancer in laboratory studies, fostering excitement about its potential for development as a new anti-cancer drug. That excitement centered on AMF-26's action in targeting a structure in cells, the Golgi apparatus, that had never been exploited in the past. The Golgi apparatus sorts and modifies hormones, enzymes and other key proteins for transport elsewhere.

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However, AMF-26 had been available in only small amounts by semisynthesis starting from AMF-14, which was extracted from the common soil mold of the genus Trichoderma.

Their report describes the first successful practical synthesis of AMF-26 and laboratory tests showing that the synthetic AMF-26 is just as effective as its natural counterpart. "The large-scale production of AMF-26 and its derivatives for the development of novel anticancer drugs are now in progress in this laboratory," the report states.



Source: Eurekalert
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