Researchers Continue Developing Treatments For Chronic Obstructive Pulmonary Disease

by Rukmani Krishna on  August 20, 2013 at 11:59 PM Respiratory Disease News
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Poor airflow due to the breakdown of lung tissue, mucus accumulation and airway dysfunction are the characteristics of chronic obstructive pulmonary disease (COPD). Development of COPD is most commonly associated with smoking tobacco, however, it also occurs after acute respiratory infections such as influenza. It is unclear how prior lung disease leads to COPD.
 Researchers Continue Developing Treatments For Chronic Obstructive Pulmonary Disease
Researchers Continue Developing Treatments For Chronic Obstructive Pulmonary Disease

In the current issue of the Journal of Clinical Investigation, Michael Holtzman and colleagues at the Washington University School of Medicine report that expression of an inflammatory molecule, interleukin-33 (IL-33), is increased in the airways of both a mouse model of viral-induced COPD and humans with COPD. Increased IL-33 was associated with an increase in mucus production, and expression of other COPD-implicated genes. The authors found in their mouse model that expression of the gene encoding IL-33 was localized to a population of lungs cells that were induced in the airway after viral infection. These results lay the groundwork for potential therapeutic strategies aimed at preventing COPD after acute lung infection.

Source: Eurekalert

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