Medindia

X

Researchers Combine Cell Transplantation And Gene Therapy For A Cure To Alzheimer's Disease

by Rukmani Krishna on  December 25, 2013 at 8:57 PM General Health News   - G J E 4
Prof. Feng Li and team from Zhongshan School of Medicine, Sun Yat-sen University in China, synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloid beta protein (Aβ) production, and introduced it into the pSilenCircle vector to construct a short hairpin (shRNA) expression plasmid against the BACE1 gene in a recent study. The study was published in the Neural Regeneration Research (Vol. 8, No. 33, 2013).
 Researchers Combine Cell Transplantation And Gene Therapy For A Cure To Alzheimer's Disease
Researchers Combine Cell Transplantation And Gene Therapy For A Cure To Alzheimer's Disease
Advertisement

Researhcers transfected this vector into C17.2 neural stem cells and primary neural stem cells, resulting in downregulation of the BACE1 gene, which in turn induced a considerable reduction in reducing Aβ protein production. This technique combining cell transplantation and gene therapy will open up novel therapeutic avenues for Alzheimer's disease, particularly because it can be used to simultaneously target several pathogenetic changes in the disease.

Advertisement
Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All