Research Sheds Light on Role of Endoplasmic Reticulum Stress in the Loss of RGCs in Diabetic Retinopathy

by Kathy Jones on  January 4, 2014 at 4:01 PM Research News
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Previous research has shown that endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy.
 Research Sheds Light on Role of Endoplasmic Reticulum Stress in the Loss of RGCs in Diabetic Retinopathy
Research Sheds Light on Role of Endoplasmic Reticulum Stress in the Loss of RGCs in Diabetic Retinopathy

According a study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013), endoplasmic reticulum stress played an important role in the hyperglycemia-induced death of ganglion cells and impairment of retinal microvessels. Tauroursodeoxycholic acid treatment effectively inhibited the activation of the endoplasmic reticulum stress pathway, and provided effective protection against diabetic retinopathy. The C/ERB homologous protein was shown to co-localize with glial fibrillary acidic protein-positive glial cells in the retina of diabetic rats, and subsequently provided evidence for the activation of glial cells in diabetic retinopathy.


Source: Eurekalert

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