Research: Nicotine Exploits COPI to Foster Addiction

by Kathy Jones on  December 31, 2013 at 7:54 PM Research News
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Researchers have always wondered how nicotine fosters addiction in individuals.
 Research: Nicotine Exploits COPI to Foster Addiction
Research: Nicotine Exploits COPI to Foster Addiction

Unexpectedly, the researchers discovered that nicotine's ability to up-regulate* nAChRs relied on the retrograde transport of ∝6* nAChRs back from the Golgi to the ER by COPI-coated vesicles. The authors believe that Golgi-ER cycling (involving COPI vesicles) may be a common mechanism for up-regulation of other nAChRs by nicotine. Manipulation of this process could therefore help form new strategies for smoking cessation and neuroprotection against Parkinson's disease.



Source: Eurekalert

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