Medindia

X

Research: New Attack on Pain

by Rukmani Krishna on  August 24, 2012 at 11:17 PM Research News   - G J E 4
The discovery of a family of molecules were related to the application of blood cell development by research. One of these, granulocyte macrophage colony-stimulating factor or GM-CSF, acts as a messenger between cells acting at a site of inflammation.
 Research: New Attack on Pain
Research: New Attack on Pain
Advertisement

Professor John Hamilton has posed the question: could blocking GM-CSF action lead to a new treatment for inflammatory diseases? In experimental models of rheumatoid arthritis, Professor Hamilton and Dr Andrew Cook had previously shown that blocking GM-CSF function with an antibody suppressed the disease leading to clinical trials which are already showing patient benefit.

Advertisement
They have now shown, in a paper that has just appeared in the world's top ranking arthritis journal, Annals of the Rheumatic Diseases, that GM-CSF depletion also suppresses pain in such models; they have also noted similar efficacy in an osteoarthritis experimental model.

"Without a doubt, quality of life and to be free from pain are important issues for people suffering with arthritis-related conditions" said Professor Hamilton.

Rheumatoid arthritis is a debilitating condition with the peak incidence being in people in their 30s and 40s. It is more common in women than in men.

"With our ageing population, the more common condition of osteoarthritis impacts more on our community and medical resources. A new therapy that can block such painful conditions would have massive benefits for health providers and governments in the future" said Dr Cook.

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All