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Research Explores Role of Single Protein in Hepatitis

by Kathy Jones on  September 16, 2014 at 8:03 PM Research News   - G J E 4
Research appearing in The Journal of Experimental Medicine says that a single protein may tip the balance between eradicating a dangerous virus from the body and enduring life-long chronic infection.
 Research Explores Role of Single Protein in Hepatitis
Research Explores Role of Single Protein in Hepatitis
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Hepatitis B and C viruses cause chronic infections in roughly three-quarters of infected people, putting these individuals at risk for developing liver diseases including cirrhosis and cancer. A few patients successfully eliminate infection, thanks primarily to virus-fighting immune cells called CD8+ T cells. The protective effects of CD8+ T cells depend on a cellular protein called T-bet, which is needed for the production of antiviral molecules like interferon.

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Scientists in Munich, Germany, have now found that high levels of T-bet in CD8+ T cells are prevalent in individuals who successfully fight off hepatitis infections but are virtually undetectable in those who don't. The presence of T-bet went hand in hand with the production of interferon and the ability of CD8+ T cells to multiply in response to the virus. Whether boosting levels of T-bet in newly infected patients will help eliminate the virus remains to be seen.



Source: Eurekalert
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