Regulator of Chronic, Low-Level Inflammation Among Overweight Patients

by Dr. Trupti Shirole on  January 24, 2016 at 10:56 PM Obesity News
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Overweight people suffer from chronic low-grade inflammation primarily in fat tissue, which has been shown to cause insulin resistance and cardiovascular disease. A new study has now revealed that the degree of chronic inflammation caused by obesity is highly dependent on levels of the signaling molecule, hydrogen sulfide, which alters the activity of a calcium channel, Orai3.
 Regulator of Chronic, Low-Level Inflammation Among Overweight Patients
Regulator of Chronic, Low-Level Inflammation Among Overweight Patients

These findings establish the possibility of targeting Orai3 as a novel treatment for the treatment of obesity-related inflammation, which has the added benefits of reducing insulin resistance and the likelihood of of developing type 2 diabetes.



This study was conducted by a team of Rosalind Franklin University researchers headed by Carl White, assistant professor of physiology and biophysics, and has been published in Science Signaling.

Source: Eurekalert

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