Protein Valuable in Forecasting the Pulmonary Metastases Risk in Breast Cancer Patients, Identified

by Nancy Needhima on  April 15, 2012 at 11:45 PM Cancer News
RSS Email Print This Page Comment
Breast cancer cells that metastasize to the lung express a higher level of the protein peroxiredoxin 2 (PRDX2) demonstrate researchers from the Bellvitge Biomedical Research Institute (IDIBELL). The study suggests that the modulation of the levels of this protein could be a new therapeutic strategy to prevent lung metastases. The study results have been advanced in the online edition of the journal Oncogene.
Protein Valuable in Forecasting the Pulmonary Metastases Risk in Breast Cancer Patients, Identified
Protein Valuable in Forecasting the Pulmonary Metastases Risk in Breast Cancer Patients, Identified
Advertisement

PRDX2 is an oxidation-reduction enzyme that protects cells against free radicals and hence from oxidative stress. This is necessary in lung cells living in an environment with plenty of oxygen. In breast cancer cells, overexpression of PRDX2 also protects against oxidative stress and promotes growth and proliferation in the lungs, i.e. metastasis.

Advertisement
New therapeutic and preventive approach

The team coordinated by the researcher of the Biological clues of the invasive and metastatic phenotype group at IDIBELL, Ŕngels Sierra, conducted several experiments in cell lines and in mice animal models which show that low levels of PRDX2's expression in tumour cells are sufficient to stop metastatic process in the lung.

"These findings," said Sierra, "suggest that modifying the expression of PRDX2 could lead to a new therapeutic approach to prevent lung metastases, as there are drugs already being tested in other diseases, capable of inhibiting the protein".

For Sierra, the next step "is to validate a sufficient number of patients with high expression of this protein as a risk biomarker of lung metastases in breast cancer. So, these patients could receive adjuvant therapy to chemotherapy to prevent lung metastases."

This study has been also developed by researchers from the INSERM of Lyon, the Biomedical Research Institute of Lleida, the University of Barcelona and the Institute of Photonic Sciences (ICFO).

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Breast Cancer Facts Cancer Facts Cancer Tattoos A Body Art Breasts - Structures and Types 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive