Protein Plays a Key Role in Spread of Tumor Growth

by Bidita Debnath on  January 27, 2014 at 11:11 PM Research News
RSS Email Print This Page Comment
Font : A-A+

A new protein has been discovered by scientists that plays a key role in spread of tumour growth, raising hope for putting a brake in spread of cancer cells.
 Protein Plays a Key Role in Spread of Tumor Growth
Protein Plays a Key Role in Spread of Tumor Growth

A team of scientists, led by David D. Schlaepfer, professor in the department of reproductive medicine at University of California, has found that a protein focal adhesion kinase - or FAK protein - gets activated in surrounding blood vessels of a tumour, enabling cancer cells to spread into the bloodstream.

"Our studies show that pharmacological or genetic inhibition of the endothelial protein focal adhesion kinase, or FAK, prevents tumour spread by enhancing the vessel barrier function," Schlaepfer said in a paper published in the Journal of Cell Biology.

Blood vessels are tightly lined with endothelial cells, which form a permeability barrier to circulating cells and molecules.

The researchers found that selective FAK inhibition within endothelial cells prevented spontaneous tumour metastasis without alterations in tumour size.

Using mouse models of breast, ovarian and melanoma tumours, first author of the paper Christine Jean showed that FAK activity was elevated in the blood vessels surrounding tumours, compared to normal tissue.

Source: IANS

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Tumor Markers For Cancer Diagnosis and Prognosis Magical Millets for Your Health The Basics of Baby Food Diet and Nutrition Tips for Athletes Nutrition IQ 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive