Medindia

X

Prolonged Fertility Window Linked To Recurrent Miscarriage

by VR Sreeraman on  January 6, 2013 at 8:03 AM Women Health News   - G J E 4
Researchers have found that a dysfunctional monthly fertility window can lead to recurrent miscarriage.
 Prolonged Fertility Window Linked To Recurrent Miscarriage
Prolonged Fertility Window Linked To Recurrent Miscarriage
Advertisement

The study, led by Professor Jan Brosens and Professor Siobhan Quenby of the Division of Reproductive Health, sheds new light on the mechanisms that determine the timing and duration of the fertility window and how that may increase the chances of miscarriage.

Advertisement
The release of the cytokine IL-33 and the activation of its receptor (ST2) in cells in the uterus induces an inflammatory response that controls the stage that we are familiar with as the two to three days of peak fertility.

Work at the Clinical Sciences Research Laboratories at University Hospital, Coventry, showed clearly that in patients with a record of recurrent pregnancy loss, this inflammatory response was prolonged. When the fertility window remains open too long, embryos implant out-of-phase into an environment that cannot support the pregnancy, which leads to miscarriage.

Professor Quenby explained what this discovery means for those who suffer from persistent pregnancy loss, "The study fundamentally changes our understanding of the issue with far reaching clinical implications. The IL-33/ST2 pathway is already considered to be a major target for therapeutic interventions across Alzheimer's, cardiovascular disease, obesity, asthma and other autoimmune disorders. We believe that targeting the same pathway in the uterus may help to prevent miscarriage by regulating the fertility window.

"It's an exciting discovery that we hope will mean new developments for a group of women for who there isn't currently any help."

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All