Prescription Glaucoma Drugs Could be Used to Treat Tuberculosis: Michigan State University

by Bidita Debnath on  July 26, 2015 at 11:32 PM Drug News
RSS Email Print This Page Comment
In a breakthrough discovery, Robert Abramovitch, a Michigan State University microbiologist, along with a graduate student have suggested that a common medication used to treat glaucoma could also be used to treat tuberculosis (TB).
 Prescription Glaucoma Drugs Could be Used to Treat Tuberculosis: Michigan State University
Prescription Glaucoma Drugs Could be Used to Treat Tuberculosis: Michigan State University
Advertisement

Researchers discovered that ethoxzolamide, a sulfa-based compound found in many prescription glaucoma drugs, actually turns off the bacterium's ability to invade the immune system. Abramovitch said that ethoxzolamide stops TB from deploying its weapons shutting down its ability to grow inside certain white blood cells in the immune system and found that the compound reduces disease symptoms in mice.

Advertisement
Abramovitch added that the compound which they found inhibits TB's ability to detect acidic environments, effectively blindfolding the bacterium so it can't resist the immune system's assault. Abramovitch and his team monitored 2,73,000 different compounds in the hope of finding one that could possibly stop the disease. By using a synthetic biosensor that glows green in response to conditions that mimic TB infection, something Abramovitch developed earlier in his research, he eventually found the needle in the haystack that turned the bacterium's sensing ability off.

Abramovitch suggested that it could help shorten the length of treatment and slow the emergence of drug resistance, particularly if found to work in conjunction with other existing TB drugs. The study has been published in Antimicrobial Agents and Chemotherapy.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Drug Toxicity Glaucoma Eye Vision Blindness Facts Drugs Banned in India Eye Redness Eye Pain Symptom Evaluation Ocular Hypertension 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive