Prenatal Risk Factors Increase Risk of Kidney Disease in Children

by Kathy Jones on  April 20, 2014 at 11:08 PM Child Health News   - G J E 4
A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN) suggests that certain prenatal risk factors are associated with the development of chronic kidney disease in children.
 Prenatal Risk Factors Increase Risk of Kidney Disease in Children
Prenatal Risk Factors Increase Risk of Kidney Disease in Children

Future studies should investigate whether modifying these factors could help protect children''s kidney health.

Risks for certain types of kidney disease may arise before birth, and researchers suspect that the development of chronic kidney disease (CKD) may be programmed prenatally. Christine Hsu, MD (University of Washington) and her colleagues sought to determine the association of childhood CKD with prenatal risk factors, including birth weight, maternal diabetes, and maternal overweight/obesity.

The researchers studied 1994 patients with childhood CKD and 20,032 controls without the disease, and the team linked maternal and infant characteristics in birth records from 1987 to 2008 to hospital discharge data.

The prevalence of CKD was 126.7 cases per 100,000 births. Infants with low birth weight were nearly three times more likely to develop childhood CKD than infants with normal birth weight. Infants were also at increased risk if their mothers developed diabetes during pregnancy of if their mothers were overweight or obese.

"We hope this research leads to further research on ways to reduce kidney disease through either early treatment or prevention that might begin even before birth," said Dr. Hsu. "Previous studies show that strict control of maternal diabetes significantly reduces the risk of congenital malformations in children. We hope our work leads to future studies to investigate whether strict control of maternal diabetes and/or reducing maternal obesity/overweight reduces childhood CKD."

Study co-authors include Kalani Yamamoto, MD, Rohan Henry, MD, Anneclaire De Roos, PhD, and Joseph Flynn, MD.

Disclosures: The authors reported no financial disclosures.

The article, entitled "Prenatal Risk Factors for Childhood CKD," will appear online at on April 17, 2014.

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Founded in 1966, and with more than 14,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.

Source: Newswise

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