Heat shock protein (HSP90) is involved in neuronal protein misfolding and accumulation in Parkinson's disease (PD) brains leading to dopaminergic neuronal death and the eventual dopamine depletion.
Therefore, HSP90 has been suggested as a therapeutic target in PD. Dr. Muhammed Al-Jarrah and co-workers from Jordan University of Science and Technology (JUST) point out exercise training significantly inhibited HSP90 overexpression in the soleus and gastrocnemius in PDe rats, which is a potential therapeutic target for ameliorating skeletal muscle abnormalities in PD. The relevant article has been published in the Neural Regeneration Research (Vol. 9, No. 6, 2014).