Post-Stroke Depression, MiR-137, Could Be a New Target

by Rukmani Krishna on  November 8, 2013 at 11:52 PM Mental Health News
RSS Email Print This Page Comment
Font : A-A+

In the occurrence and development of depression MiRNAs play an important role, and can be used as potential targets for treatment of depression.
 Post-Stroke Depression, MiR-137, Could Be a New Target
Post-Stroke Depression, MiR-137, Could Be a New Target

Studies have shown that miR-137 expression is downregulated in the brain from depression patients with suicidal behavior. Moreover, miR-137 expression is also downregulated in peripheral blood from stroke patients. However, it is not yet known if miRNAs are associated with post-stroke depression.

To test this, Dr. Lixia Zhao and colleagues from Shandong Provincial Hospital, China used middle cerebral artery occlusion and chronic mild stress to establish a post-stroke depression model in rats. Compared with controls, the researchers found significantly lower miR-137 levels in the brain and peripheral blood from post-stroke depression rats. Injection of a miR-137 antagonist into the brain ventricles upregulated miR-137 levels, and improved behavioral changes in post-stroke depression rats. Luciferase assays showed miR-137 bound to the 3′UTR of Grin2A, regulating Grin2A expression in a neuronal cell line.

Grin2A gene overexpression in the brain of post-stroke depression rats, noticeably suppressed the inhibitory effect of miR-137 on post-stroke depression. Overall, these results, published in the Neural Regeneration Research (Vol. 8, No. 26, 2013), show that miR-137 suppresses Grin2A protein expression through binding to Grin2A mRNA, thereby exerting an inhibitory effect on post-stroke depression. Our results offer a new therapeutic direction for post-stroke depression.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Depression Modified Atkins Diet: All You Need to Know 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive