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Possible Target For Treating Autoimmune Diseases Uncovered

by priya on  January 27, 2009 at 12:48 PM Genetics & Stem Cells News
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Possible Target For Treating Autoimmune Diseases Uncovered
Scientists from University of California claim to have identified a potential therapeutic target for autoimmune diseases.


They have discovered an abnormality in a patient’s immune system that may lead to safer therapies for autoimmune diseases such as rheumatoid arthritis and colitis, as well as potential new ways to treat transplant rejection.

While studying a woman patient with frequent infections in the ears, urinary tract and lungs, the researchers identified antibodies from the immune system that prevent infection-fighting T cells from moving through her blood stream and entering her body’s organs to attack invaders such as bacteria or viruses.

Autoimmunity occurs when the body perceives its own cells or tissue as foreign organisms and creates an immune response to itself and the majority of the sufferers are women.

"This is the first selective antibody of its type discovered in a patient," said lead study author Edward J. Goetzl, MD, UCSF professor of medicine and immunology.

"Antibodies that react more generally against blood cells, such as T cells, previously have been identified. However, this is the first to block a specific aspect of T-cell function.

"Our study offers a potential new approach to developing safer, more targeted therapies based on human antibodies," he added.

The woman involved in the study had low number of blood T cells.

The studies revealed that the patient’s CD4 T cells did not move out of her lymph nodes as they would in a normal immune system because her body created antibodies to one type of sphingosine 1-phosphate (S1P) receptor.

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