Physical or Mental Stress Before Cancer Therapy may Sabotage Treatment

A new research has suggested that patients who experience physical or psychological stress - including rigorous exercise - one or two days before a cancer treatment might be unknowingly sabotaging their therapy.

Stress in the body - even physical stress caused by intense exercise - activates a stress-sensitive protein that can spark a series of events that allow cancer cells to survive such treatments as chemotherapy and radiation, according to the research.

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Though the study involved a series of experiments in breast cancer cell cultures, the researchers say the findings are a clear indication that cancer cells have found a way to adapt and resist treatment with the help of this stress-inducible protein.

This cancer cell survival can be traced to the presence of heat shock factor-1, which previous research has linked to stress.

Ohio State University researchers first noticed that this common protein can help heart tissue survive in a toxic environment, leading the scientists to suspect that in cancer, this phenomenon could have serious consequences.

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A series of experiments using breast cancer cells showed that a protein activated by the presence of heat shock factor-1 could block the process that kills cancer cells even after the cells' DNA was damaged by radiation. The same was true when the cells were subjected to a common chemotherapy drug.

The researchers hope to develop a drug that could suppress heat shock factor-1 as a supplement to cancer therapy, but in the meantime, they recommend that patients avoid both psychological and physical stress in the days leading up to a cancer treatment.

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Researchers have developed a heat therapy, which when used with chemotherapy destroys large breast cancer tumors, at the University of Oklahoma.

The study appears online in the journal Molecular Cancer Research.

Source-ANI

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