With the help of molecular imaging with positron emission tomography (PET) researchers have unveiled the possible positive and negative effects of caffeine consumption on human brain. According to the new study, PET imaging with F-18-8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (F-18-CPFPX) shows that repeated intake of caffeinated beverages throughout a day results in up to 50 percent occupancy of the brain's A1 adenosine receptors.
"The effects of caffeine to the human body are generally attributed to the cerebral adenosine receptors. In the human brain the A1 adenosine receptor is the most abundant," David Elmenhorst, lead author of the study, said.
"In vitro studies have shown that commonly consumed quantities of caffeine have led to a high A1 adenosine occupancy. Our study aimed to measure the A1 adenosine receptor occupancy with in vivo imaging," he said.
Fifteen male volunteers participated in the study. They abstained from caffeine intake for 36 hours and then underwent a PET scan with F-18-CPFPX. Caffeine was then introduced in short intravenous infusions, increasing in amount.
To estimate the occupancy of A1 adenosine receptors by caffeine, the distribution volume at the baseline period of the PET scan was compared with the distribution volume after caffeine administration.
Researchers determined that the concentration of the caffeine that displaces 50 percent of the binding of F-18-CPFPX to the A1 adenosine receptor was 13 mg/L, or approximately four to five cups of coffee.
Advertisement
"There is substantial evidence that caffeine is protective against neurodegenerative diseases like Parkinson's or Alzheimer's disease," Elmenhorst said.
Advertisement
"The present study provides evidence that typical caffeine doses result in a high A1 adenosine receptor occupancy and supports the view that the A1 adenosine receptor deserves broader attention in the context of neurodegenerative disorders," he said.
The study has been published in The Journal of Nuclear Medicine.
Source-ANI