PD-L1 Plays an Important Role in the Pathogenesis of Multiple Sclerosis

by Bidita Debnath on  March 15, 2014 at 6:11 PM Research News
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Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathogenesis and pathology.
 PD-L1 Plays an Important Role in the Pathogenesis of Multiple Sclerosis
PD-L1 Plays an Important Role in the Pathogenesis of Multiple Sclerosis

Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. Therefore, Qun Xue, Fanli Dong and co-workers from the First Affiliated Hospital of Soochow University in China speculated that programmed cell death 1 ligand 1 (PD-L1) plays an important role in the pathogenesis of multiple sclerosis.

A recent study by these researchers published in the Neural Regeneration Research (Vol. 8, No. 35, 2013) found that the expression of PD-L1 in the spinal cord and splenocytes of mice with experimental allergic encephalomyelitis was significantly increased compared with normal mice. This evidence provides the basement for exploring the role of PD-L1 in multiple sclerosis.

Source: Eurekalert

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