Two common genetic variants that are believed to be associated with memory performance have been discovered by an international researcher team in the largest study of genetics of memory ever undertaken. The team included scientists from Boston University School of Medicine (BUSM).
Longer life spans and the increased prevalence of memory impairment and dementia world-wide underscore the critical public health importance of efforts aimed at deciphering the underlying mechanisms of human memory.
Nearly 30,000 participants who did not have dementia were included in the study. Each participant completed memory tests, such as word recall, and their entire genome was genotyped. Using sophisticated statistical analysis, the genome was examined for segments that were associated with low memory scores.
The researchers found genetic variants near the Apolipoprotein E gene, known to harbor an increased risk of dementia (especially Alzheimer disease), were associated with poorer memory performance, mostly so in the oldest participants and for the short story recall. In a sub-study with post-mortem brain samples, participants with an increasing load of memory risk variants also had more pathological features of Alzheimer disease, perhaps reflecting in some instances early pre-clinical stages of the disease.
According to the researchers two additional regions of the genome, pointing to genes involved in immune response, were associated with the ability to recall word lists, providing new support for an important role of immune system dysfunction in age-related memory decline.
Lead author fop the study, Dr. Stephanie Debette said that the genetic variants associated with memory performance also predicted altered levels of expression of certain genes in the hippocampus, a key region of the brain for the consolidation of information. These were mainly genes involved in the metabolism of ubiquitin that plays a pivotal role in protein degradation.
This unprecedented world-wide collaboration has generated novel important hypotheses on the biological underpinnings of memory decline in old age, however the researchers cautioned that more research was clearly needed to confirm the findings.
The study is published in the journal Biological Psychiatry.