Oxford University Scientist Identifies Cancer's Food Sensors

by Bidita Debnath on  October 7, 2015 at 4:25 AM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

A researcher from Oxford University has identified a protein used by cancer tumors to help them detect food supplies. Initial results show that targeting the protein could restrict cancerous cells' ability to grow.
 Oxford University Scientist Identifies Cancer's Food Sensors
Oxford University Scientist Identifies Cancer's Food Sensors

"We found that aggressive cancer cells manufacture more protein named PAT4 which enables them to make better use of available nutrients than the cells around them - including healthy tissue," said Dr Deborah Goberdhan, an Indian-origin researcher from Oxford University's department of physiology, anatomy and genetics.

Cancer cells often have restricted access to the body's nutrient-rich blood supply. The ability to sense and acquire nutrients is critical for a cancer to grow. Dr Goberdhan and cancer researcher Adrian Harris collaborated to develop an antibody that could be used to highlight PAT4 in human tissue samples.

This was then used to study anonymous tumor samples taken from patients with colorectal cancer, a common form of the disease. The results were compared to the known outcomes for the patients.

Those who had higher levels of PAT4 in their tumors did less well than those with lower levels - being more likely to relapse and die. The researchers then looked at what happened when PAT4 levels were reduced. They showed that by reducing PAT4 levels, cancerous tumors grew more slowly.

"'These findings support each other. Not only do higher levels of PAT4 mean a worse outcome, but lowering levels improves the situation," Dr Goberdhan pointed out. "This means that we have identified a mechanism which cancer cells prefer to use and which we might be able to target as part of a combination treatment," he concluded.

The research was published in the science journal Oncogene.

Source: IANS

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Why Do We Eat - Nutrition Facts Diet Lifestyle and Heart Disease Hunger Fullness and Weight Control Label Lingo on Food Items: Decoded Tips for Healthy Fasting During Ramadhan Top Diet Foods that Make you Fat Top Food for Dieters Selenium - Natural Source Better than Supplements Common Lifestyle Habits that Cause Diseases 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive