Organs During Transplantation Protected by Drugs Preventing Blood Clot

by Himabindu Venkatakrishnan on  November 18, 2014 at 3:20 PM Drug News
RSS Email Print This Page Comment bookmark
Font : A-A+

During transplantation, organs can become significantly damaged. A protective strategy to keep them safe and allow them to function optimally after the procedure has been offered in a new article published in the BJS (British Journal of Surgery).
 Organs During Transplantation Protected by Drugs Preventing Blood Clot
Organs During Transplantation Protected by Drugs Preventing Blood Clot

When an organ is transplanted from a donor to a recipient, there is a period of time when the organ is deprived of normal blood flow. While this in itself can cause tissue damage, additional damage may also occur when blood flow is restored to the organ due to a high risk of blood clotting.

Investigators led by Thierry Hauet, MD, PhD, of the Institut National de la Santé et de la Recherche Médicale (INSERM), the University of Poitiers, and the Centre Hospitalier Universitaire (CHU) de Poitiers, in France, wondered whether anticoagulants or "blood thinners" might help protect transplant organs against these effects. The team tested the potential of fondaparinux in an experimental model of kidney transplantation. Use of the anticoagulant was linked with improved kidney function both immediately after transplantation and several months later.

"People die every day from the lack of available organs. This study demonstrates the benefits of anticoagulation therapy using new and original drugs at the time of organ collection," said Dr. Hauet. "Such therapy could augment the pool of available organs and allow for the safe use of marginal organs, which have characteristics associated with poorer outcomes or come from donors with medical complexities."

Such an anticoagulation strategy could be an important addition to current transplant protocols to limit tissue damage and improve outcomes in patients receiving kidney, liver, pancreas, lung, heart, and other organ transplants.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Drug Toxicity Thalassemia Anticoagulants von Willebrand Disease Deep Vein Thrombosis Drugs Banned in India Pulmonary Embolism Hemophilia Transplantation Organ Donation and Transplantation 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive