Medindia

X

On a Mission to Find How Cigarette Smoking Weakens Bones

by Nancy Needhima on  July 26, 2012 at 2:41 PM Research News   - G J E 4
Nearly 20 years since scientists first identified cigarette smoking as a risk factor for osteoporosis and bone fractures, a fresh study is clarifying exactly how cigarette smoke weakens bones. The report, in ACS' Journal of Proteome Research, concludes that cigarette smoke makes people produce excessive amounts of two proteins that trigger a natural body process that breaks down bone.
On a Mission to Find How Cigarette Smoking Weakens Bones
On a Mission to Find How Cigarette Smoking Weakens Bones
Advertisement

Gary Guishan Xiao and colleagues point out that previous studies suggested toxins in cigarette smoke weakened bones by affecting the activity of osteoblasts, cells which build new bone, and osteoclasts, which resorb, or break down, old bone. Weakening of the bones, known as osteoporosis, can increase the risk of fractures and is a major cause of disability among older people. To shed light on how cigarette smoking weakens bones, the scientists analyzed differences in genetic activity in bone marrow cells of smokers and non-smokers.

Advertisement
They discovered that human smokers produce unusually large amounts of two proteins that foster production of bone-resorbing osteoclasts compared to non-smokers. Experiments with laboratory mice confirmed the finding.

The authors acknowledge funding from the Cancer and Smoking Related Disease Research Program and the Nebraska Tobacco Settlement Biomedical Research Program.

Journal of Proteome Research

ACS NEWS SERVICE

Source: ACS News Service
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All