Obesity Gene Linked to Weight Gain

by Dr. Enozia Vakil on  May 25, 2014 at 6:37 PM Research News
RSS Email Print This Page Comment
FTO, the gene commonly associated with obesity, may actually contribute to weight gain, a new study has found.

The study shows that variations in FTO indirectly affect the function of the primary cilium, a little-understood hair-like appendage on brain and other cells.
 Obesity Gene Linked to Weight Gain
Obesity Gene Linked to Weight Gain
Advertisement

Specific abnormalities of cilium molecules, in turn, increase body weight, in some instances, by affecting the function of receptors for leptin, a hormone that suppresses appetite.

Advertisement
The findings, made in mice, suggest that it might be possible to modify obesity through interventions that alter the function of the cilium, according to scientists at Columbia University Medical Center (CUMC).

"If our findings are confirmed, they could explain how common genetic variants in the gene FTO affect human body weight and lead to obesity," study leader Rudolph L. Leibel, MD, the Christopher J. Murphy Memorial Professor of Diabetes Research, professor of pediatrics and medicine, and co-director of the Naomi Berrie Diabetes Center at CUMC, said.

"The better we can understand the molecular machinery of obesity, the better we will be able to manipulate these mechanisms and help people lose weight," he said.

The study is published in the online edition of Cell Metabolism.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Bariatric Surgery DNA Finger Printing Obesity Diabetes - Essentials Binge Eating : The Pleasure and Pain Bulimia Nervosa Height and Weight-Kids Body Mass Index Liposuction Exercise To Gain Weight 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive