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Novel Shot to Reverse Arthritis

by Sheela Philomena on  April 13, 2012 at 11:57 AM Research News   - G J E 4
Kartogenin molecule helps repair damaged cartilage and reverse debilitating conditions like arthritis.

Currently these is no cure for the condition, only anti-inflammatory painkillers to relieve symptoms, and in severe cases, costly joint replacements are advised.
 Novel Shot to Reverse Arthritis
Novel Shot to Reverse Arthritis
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Main symptoms of arthritis include pain, stiffness and restricted movement in the joints, and in the UK it affects more than nine million people alone, the journal Science reports.

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Researchers at the Genomics Institute of the Novartis Research Foundation in San Diego and Scripps Research Institute in La Jolla, California, US, said: "This may ultimately lead to a stem-cell based therapy for osteoarthritis," according to the Daily Mail.

During the study, 22,000 drug-like molecules were tested using a robotic screen, applying each one to bone marrow stem cells. When kartogenin was administered to mice with osteoarthritis-like symptoms, it prompted stem cells to change into cartilage cells.

A patent has already been filed, however more work is needed to understand exactly how the molecule works. Judith Brodie, chief executive of Arthritis Care, said: "We are delighted with any potential breakthrough for people with arthritis."

Source: IANS
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